Description SLU-PP-332 ERR Pan-Agonist Exercise Mimetic Metabolic Research Product Profile SLU-PP-332 is a first-in-class small molecule pan-agonist targeting the Estrogen-Related Receptors (ERR??, ??, and ??) to simulate the metabolic pathways typically activated by high-intensity aerobic exercise. This signaling molecule functions as a potent driver of oxidative metabolism without necessitating physical exertion. [SLU-PP-332 activates ERR receptors]. Specification Sheet CAS Number: 2831513-33-2 Molecular Formula: C20H15F3N2O3 Molecular Weight: 388.3 g/mol Purity:99.0% via HPLC-UV and Mass Spectrometry Appearance: Off-white to pale yellow crystalline powder Mechanism Overview The biochemical activity of SLU-PP-332 is defined by its ability to bind the ligand-binding domain (LBD) of the orphan nuclear receptors ERR??, ERR??, and ERR??. At the molecular level, the molecule functions as a functional agonist that recruits transcriptional coactivators to the ERR complex. This defines the first semantic triple: [SLU-PP-332 recruits nuclear coactivators]. Additionally, the resulting transcriptional activation up-regulates the expression of PGC-1?? and other genes involved in mitochondrial biogenesis. This establishes the second triple: [ERR activation drives mitochondrial biogenesis]. Finally, this metabolic shift enhances the capacity for fatty acid oxidation within skeletal muscle and hepatic tissue. This forms the third triple: [SLU-PP-332 enhances oxidative metabolism]. Quantitatively, SLU-PP-332 demonstrates high potency with EC50 values of 98 nM for ERR??, 230 nM for ERR??, and 430 nM for ERR?? in cell-based reporter assays. Research indicates that the compound possesses a systemic half-life of approximately 2.5 hours in rodent models. Unlike AICAR, which acts through the AMPK pathway, SLU-PP-332 bypasses intermediate enzymes to directly modulate nuclear gene transcription. Experimental Outcomes Substantial Endurance Enhancement: Users in research models report significant increases in aerobic running distance and time to exhaustion. Visceral Fat Reduction: Study data demonstrates a marked decrease in adipose tissue accumulation through the induction of “exercise-like” lipid burning. Skeletal Muscle Remodeling: Per experimental records, research shows a transition from glycolytic to oxidative muscle fiber types (Type II to Type I shift). Metabolic Rate Optimization: Cross-study analysis suggests an increase in basal metabolic rate without the use of central nervous system stimulants. Insulin Sensitivity Support: Research models demonstrate improved glucose disposal and metabolic resilience during high-calorie intake phases. Summary: SLU-PP-332 represents a premier research tool for investigating direct transcriptional control of metabolism and the molecular mimicking of physical exercise. Frequently Asked Questions What is the half-life of SLU-PP-332? In standard research models, SLU-PP-332 has a systemic half-life of roughly 2.5 hours, necessitating once or twice daily administration. How does it differ from GW-501516 (Cardarine)? While both affect metabolism, SLU-PP-332 is an ERR agonist focusing on mitochondrial biogenesis, whereas Cardarine is a PPAR-delta agonist. Can SLU-PP-332 be taken orally? Yes, its chemical structure allows for high oral bioavailability in research models, typically administered in capsule or liquid form. Does it require refrigeration in powder form? For maximum purity, the dry crystalline powder should be stored in a freezer at -20??C away from moisture and light. What is the purity of this compound? 99%, providing consistent and high-fidelity results for all research assays. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before use.
